ChREBP Rather Than SHP Regulates Hepatic VLDL Secretion
نویسندگان
چکیده
منابع مشابه
ChREBP Rather Than SHP Regulates Hepatic VLDL Secretion
The regulation of hepatic very-low-density lipoprotein (VLDL) secretion plays an important role in the pathogenesis of dyslipidemia and fatty liver diseases. VLDL is controlled by hepatic microsomal triglyceride transfer protein (MTTP). Mttp is regulated by carbohydrate response element binding protein (ChREBP) and small heterodimer partner (SHP). However, it is unclear whether both coordinatel...
متن کاملHepatic insulin signaling regulates VLDL secretion and atherogenesis in mice.
Type 2 diabetes is associated with accelerated atherogenesis, which may result from a combination of factors, including dyslipidemia characterized by increased VLDL secretion, and insulin resistance. To assess the hypothesis that both hepatic and peripheral insulin resistance contribute to atherogenesis, we crossed mice deficient for the LDL receptor (Ldlr-/- mice) with mice that express low le...
متن کاملInactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion.
Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased activity of these enzymes. The mechanism responsible for the low LDL-cholesterol levels associated with ANGPTL3 deficiency is not known. Here we used ...
متن کاملGamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion.
AIM Present study aimed to elucidate the suppression of serum lipids by gamma- and delta-tocotrienol (γδT3). METHODS The lipid-lowering effects of γδT3 were investigated using HepG2 liver cell line, hypercholesterolemic mice and borderline-high cholesterol patients. RESULTS In-vitro results demonstrated two modes of action. First, γδT3 suppressed the upstream regulators of lipid homeostasis...
متن کاملVLDL Hydrolysis by Hepatic Lipase Regulates PPARδ Transcriptional Responses
BACKGROUND PPARs (α,γ,δ) are a family of ligand-activated transcription factors that regulate energy balance, including lipid metabolism. Despite these critical functions, the integration between specific pathways of lipid metabolism and distinct PPAR responses remains obscure. Previous work has revealed that lipolytic pathways can activate PPARs. Whether hepatic lipase (HL), an enzyme that reg...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nutrients
سال: 2018
ISSN: 2072-6643
DOI: 10.3390/nu10030321